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Pre-Clinical IHC Tools for Mouse Models

Enabling translational research with anti-mouse tumor immunology antibodies for IHC

Mouse models are valuable pre-clinical research tools. First, they are genetically and biologically similar to humans. Secondly, they mimic human disease states without the tissue sample limitations of human models. However, mouse monoclonal antibodies suffer from secondary antibody-related background when used on mouse tissue. Rabbit monoclonal antibodies are an ideal solution to this problem.

Don’t settle for sub-optimal reagents that don’t cover all your research needs.

We are continually expanding our portfolio of mouse-reactive, IHC validated antibodies against the most important tumor immunology targets. Our IHC validated rabbit monoclonal antibodies demonstrate the exceptional specificity, sensitivity, and performance required for credible results in challenging applications such as IHC, while eliminating problems seen with mouse-on-mouse staining.

We work with syngeneic mouse models, as well as normal mouse tissues, to confirm specificity in the same pre-clinical models our customers are using. This provides an extra data point, showing the protein of interest is expressed within a tumor model, not just in a given tissue. We also perform staining using the Leica® Bond Rx, a familiar platform to many researchers. You can be confident that these antibodies will perform as expected, and you can save time using the product-specific autostainer protocols we’ve already validated.

Cell Signaling Technology-validated anti-mouse rabbit monoclonal antibodies for immunohistochemistry reduce background, providing clearer results and reducing experiment turnaround time. We have the expertise and the data to be your most reliable pre-clinical partner for IHC solutions.

Examples of mouse model systems used to validate our antibodies

F4/80

F4/80 Mouse Model Data

Immunohistochemical analysis of various paraffin-embedded syngeneic mouse tumors using F4/80 (D2S9R) XP® Rabbit mAb #70076. F4/80 is a cell surface protein and known marker of mouse macrophage populations.

CD4

CD4 Mouse Model Data

Immunohistochemical analysis of various paraffin-embedded syngeneic mouse tumors using CD4 (D7D2Z) Rabbit mAb #25229. CD4 is a cell surface marker known to be expressed on T cells.

TIM-3

TIM-3 Mouse Model Data

Immunohistochemical analysis of various paraffin-embedded syngeneic mouse tumors using TIM-3 (D3M9R) XP® Rabbit mAb (Mouse Specific) #83882.

VISTA

VISTA Mouse Model Data

Immunohistochemical analysis of various paraffin-embedded syngeneic mouse tumors using VISTA (D5L5T) XP® Rabbit mAb #54979.

S100A9

S100A9 Mouse Model Data

Immunohistochemical analysis of various paraffin-embedded syngeneic mouse tumors using S100A9 (D3U8M) Rabbit mAb (Rodent Specific) #73425.

PD-1

PD-1 Mouse Model Data

Immunohistochemical analysis of various paraffin-embedded syngeneic mouse tumors using PD-1 (D7D5W) XP® Rabbit mAb (Mouse Specific) #84651.

CD11c

CD11c Mouse Model Data

Immunohistochemical analysis of various paraffin-embedded syngeneic mouse tumors using CD11c (D1V9Y) Rabbit mAb #97585.